One of the most common active ingredients you’ll find in shampoos for treating both seborrheic dermatitis and scalp psoriasis is salicylic acid. Salicylic acid can be used alone but is often combined with other treatments to help relieve itching, flaking and redness of the skin and scalp.
We’ve reviewed a ton of salicylic shampoos over the years and before we tell you our favorites, it’s worth going over what the active ingredient is, what it does and what conditions it can help.
Giving you the information you need make your own mind up whether it’s the active ingredient for you…
Salicylic acid is a keratolytic and anti-inflammatory active ingredient, widely used to treat skin and scalp conditions. There are numerous licensed products and applications of salicylic acid, ranging from 12.0% gels for treating verrucas, to co-formulation with prescription-only steroids in the treatment of psoriasis.
The use of different salicylic acid formulations means that the directions for use vary significantly. For scalp conditions, most salicylic acid shampoos are concentrated at 1.8 to 3%, and need to be massaged thoroughly into the scalp, before leaving for a few minutes and rinsing out . This process should be repeated daily to every few days – but always make sure to read the label before using a medicated shampoo!
A Brief History of Salicylic Acid
Salicylic acid has an intriguing history, being a chemical precursor to ‘acetylsalicylic acid’ – more commonly known as aspirin. The watery bark sap of the willow tree (Salix alba) contains high concentrations of salicylic acid, which can be refined to make aspirin.
Salicylic Acid Crystals
For the past 120 years, aspirin has been used as a painkiller and anti-inflammatory, but now is more commonly used as an antiplatelet in the secondary prevention of cardiovascular disease . The discovery of aspirin in the late 19th Century by the pharmaceutical company Bayer led to the creation of a new class of medications, the ‘non-steroidal anti-inflammatory drugs’ (NSAIDs). Research into the pharmacological mechanism of aspirin underpins our current understanding of inflammatory pathways, for which John Robert Vane, Sune Bergström, and Bengt Ingemar Samuelsson were awarded the 1982 Nobel Prize in Medicine .
How does Salicylic Acid work?
Salicylic acid is very closely related to aspirin, but they don’t have the same roles in the treatment of scalp conditions. Salicylic acid is used in shampoos, creams, and ointments mainly for keratolytic effects and local anti-inflammatory action. Keratolytic agents cause cells of the epidermis to shed more easily, helping to remove dry and flaky skin . You’ll often see salicylic acid referred to as an exfoliator.
The keratolytic effects of salicylic acid are also used in certain products to increase the penetration of corticosteroids. This can be necessary for dermatological conditions, where plaques and thickened skin prevent steroids from being absorbed into tissue – reducing efficacy .
For a long time, seborrheic dermatitis was seen as a condition caused by excessive growth of skin cells (‘hyperproliferation), explaining the characteristic symptoms: flaky skin, itchiness, greasy skin. This rationalized the use of salicylic acid in shampoos. It’s now better understood that Malassezia yeasts play a role in the underlying condition, and so antifungal treatments are more useful first-line options (e.g. ketoconazole, selenium sulfide) .
Salicylic acid does not possess any antifungal properties necessary for the treatment of seb derm, but the keratolytic effects can help to remove flaky skin. The salicylic acid softens the existing build up while the anti-fungal can help prevent any further build up.
In addition, a recent study suggests that the presence of salicylic acid with an anti-fungal can help amplify the power of that anti-fungal agent. 
Scalp Psoriasis is an auto-immune condition causing the hyperproliferation growth of skin cells. In a regular skin cycle skin, the turnover of skin cells takes about a month. If you have psoriasis, it can happen within a few days.
As a result, a number of raised plaques or patches of thick, scaly skin appear on various parts of your body.
The keratolytic properties of salicylic acid can help to soften and remove the flaky skin.
In severe cases of psoriasis, treatment is often combined with a topical steroid – the salicylic acid added to help penetration of the steroid – the scaly build up can prevent the steroid from entering the skin efficiently .
What are the risks?
Salicylic acid shampoos are generally well-tolerated but should be avoided in those with a history of aspirin allergy. Only a very small amount of salicylic acid is absorbed into the bloodstream when applied to healthy skin. But this figure increases around 150 times when the skin is damaged (although this figure is for creams, and so will be lower for rinse-off shampoos). Toxicity has been reported, but these cases are typically associated other contributory factors .
Systemic absorption is unlikely to result in any harm but reinforces that the lowest effective quantity should be used for the least amount of time. Typically in scalp conditions, this means using a medicated shampoo for two to four weeks, but exact recommendations vary by formulation and brand. Prolonged use of a keratolytic agent can also cause dry skin – worsening symptoms – and so excessive use should be avoided.
Salicylic Acid Shampoo Reviews
Below is a list of the best salicylic shampoos we’ve reviewed so far.
Dead Sea Spa MAGIK Mineral Shampoo is a combination shampoo containing both salicylic acid and zinc pyrithione. The thinking behind this shampoo is that the salicylic acid will soften and exfoliate existing build up and the zinc pyrithione will help prevent new build up from forming.
I’m generally a big fan of combination shampoos and this is no exception. The shampoo feels great, has a nice light smell and leaves the hair feeling extremely soft. It only contains one known contact allergen too - cocamidopropyl betaine.
If you suffer from mild seb derm I can’t recommend this highly enough.
One of the best and mildest shampoos out there for seb derm sufferers with sensitive skin.
Containing both Piroctone Olamine and Salicylic Acid as well as being SLS free, paraben free, artificial color free this shampoo has an absolutely outstanding choice of active and inactive ingredients.
There are still two or three chemicals in there that some may find irritating. Otherwise this would have been a five out of five performer.
Quite simply the best pure Salicylic Acid shampoo we’ve yet reviewed. The shampoo contains 3% Salicylic Acid combined with a fragrance free, sulfate free and virtually every other nasty ingredient free formulation. It does this and still feels luxurious when washing.
Neutrogena should be exceptionally proud of this top top class shampoo.
La Roche Posay is a combination shampoo, combining both Piroctone Olamine and Salicylic Acid. The Salicylic Acid will help exfoliate existing dandruff build up while the Piroctone Olamine is designed to prevent any new outbreaks. It’s a match made in heaven.
I can’t let a mention of a review pass without commenting on how luxurious this shampoo feels and smells when washing – better than any medicated shampoo I have ever tried. And I’ve tried lots!
There are a couple of harsh ingredients but compared to the majority of the shampoos on the market, this is a first class Piroctone Olamine shampoo.
Regenure DR Hair and Scalp Treatment is a 1% Ketoconazole formulation shampoo combined with Salicylic Acid. The company ave been particularly clever with their formulation and marketing – positioning the shampoo as a gentler alternative to Nizoral. The company have largely achieved that too. Adding Salicylic Acid to get rid of the dandruff and ketoconazole to remove the dandruff is an inspired combination too.
That said, it’s still a 1% ketoconazole shampoo. Given the choice I’d choose 2% every time, but this would require a prescription in Regenpures largest market – the USA.
Bioderma Nodé DS+ shampoo certainly packs an anti-dandruff punch. Its combination of anti-dandruff actives (Piroctone Olamine and Zinc Pyrithione), with keratolytic Salicylic Acid and anti-inflammatory Sodium Shale Oil Sulfonate are also complimented by several scalp soothing ingredients. A heck of an ingredients list only let down by the use of SLES and one or two other potential irritants.
If there’s any we haven’t reviewed then please drop us a note and we’ll be absolutely delighted to look into it!
 EMC. (2015). Capasal Therapeutic Shampoo. [Accessed: 12/3/17] www.medicines.org.uk
 Vane, J. R., & Botting, R. M. (2003). The mechanism of action of aspirin. Thrombosis Research, 110(5), 255-258.
 Nobel Assembly of Karolinska Institutet. (1982). Press Release: The Nobel Prize in Physiology or Medicine 1982. [Accessed: 12/3/17] www.nobelprize.org
 Fluhr, J. W., Cavallotti, C., & Berardesca, E. (2008). Emollients, moisturizers, and keratolytic agents in psoriasis. Clinics in Dermatology, 26(4), 380-386.
 Williams, A. C., & Barry, B. W. (2012). Penetration enhancers. Advanced Drug Delivery Reviews, 64, 128-137.
 DeAngelis, Y. M., Gemmer, C. M., Kaczvinsky, J. R., Kenneally, D. C., Schwartz, J. R., & Dawson, T. L. (2005, December). Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity. Journal of Investigative Dermatology Symposium Proceedings. Vol. 10, No. 3, pp. 295-297.
 da Rocha Neto, Maraschin, Di Piero (2015). Antifungal activity of salicylic acid against Penicillium expansum and its possible mechanisms of action.
 Madan, R. K., & Levitt, J. (2014). A review of toxicity from topical salicylic acid preparations. Journal of the American Academy of Dermatology, 70(4), 788-792.
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.